Effect of aloe vera leaf extract on alloxan induced diabetes in young mice j. Alloxan has been shown to induce free radical production and cause tissue injury. In spite of continuous new drug development to treat. Decreased body weight is commonly observed in alloxaninduced diabetic rodents. Antidiabetic effect of sida cordata in alloxan induced diabetic rats. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that.
Alloxaninduced diabetic rats as described elsewhere 7, male wistar rats 190210 g body weight were injected with alloxan 110 mgkg through intraperitonial route. Eighteen adult male wistar rats weighing 180 to 230 g were randomly divided into 3 equal groups including. Antidiabetic effect of artemisia absinthium extracts on. Department of zoology, sadguru gadage maharaj college, karad 415110, india available online. Antihyperglycemic and antidyslipidemic activity of musa.
Antioxidant, antihyperglycemic, and antihyperlipidemic. Effect of shilajit on blood glucose and lipid profile in alloxaninduced diabetic rats n. Comparative study of the antioxidant effects of metformin. Alloxaninduced diabetes delays repair in a rat model of. Diabetic rats were given macerated preparation of allium sativum garlic at a dose of 6. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mgkg i. The mechanisms responsible for failure of glycaemic control in diabetes need to be thoroughly elucidated and hence the present study was initiated.
Effect of crude oil pollution on phytochemical and anti. Diabetes is usually accompanied by increased production of free radicals or. Honey treatment did not improve % change in body weight in diabetic rats. Objectives this study is aimed at investigating the effect of crude oil pollution on the phytochemical content and anti diabetic potentials of oxytenanthera abyssinica rhizomes in normal and alloxan induced diabetic rats using standard methods. The elevated of blood glucose, free fatty acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances that lead to. Comparison of streptozotocin and alloxaninduced diabetes. The present study investigated the antioxidant effects of three standard antidiabetic agents belonging to three different classes, metformin met, glibenclamide gli, and repaglinide rep, in alloxaninduced diabetic rats. Diabetes was induced by a single intraperitoneal injection of alloxan 150 mgkg b. Biochemical effects of hydroclathrus clathratus on alloxan. Aloe vera is used worldwide for several medical purposes as alternative medicine. Hypoglycemic activity of cucumis sativus extract on.
Alloxaninduced and insulinresistant diabetes mellitus. Histopathological assessment of the kidney of alloxan. The present study was carried out to evaluate the antidiabetic effect of psidium guajava leaves extract and to study the activities of hexokinase, aldolase and phosphor glucoisomerase, and gluconeogenic enzymes such asglucose6phosphatase and. The extract did not produce hypoglycemic activity at both the dose levels in normal, fasted rats. The present study investigates the preventive effect of fasting in alloxaninduced diabetic rats. Alloxaninduced diabetes is a form of insulin dependent diabetes mellitus that. The diabetic rats which showed blood glucose levels in. Histopathological study of the liver of alloxan induced diabetic rats and macerated allium sativum garlic ameliorative effect.
The methanolic whole plant extract at high dose 500 mgkg exhibited significant antihyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Biochemical and haematological effects of the leaf extract. The study found that alloxaninduced diabetic rats exhibited significant % reduction in body weight. Alloxan induced insulin release is, however, of short duration and is followed by complete suppression of the islet response to glucose, even when high concentrations 16. Extract ethanol of poguntano in alloxan induced diabetic rats. Pdf antidiabetic activity of extract on alloxan induced diabetic rats. Antidiabetic, hypolipidemic and histopathological analysis of. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. Extract in alloxan induced diabetic rats enas ali kamel mohamed lecturer in biochemistry and nutrition department womens college, ain shams university abstract. This is attributed to break down of adipose tissue lipids and skeletal muscle protein. It has been estimated that up to onethird of patients with diabetes mellitus use some form. Pdf diabetes mellitus is affecting many in workforce, thus have a major impact on both individual and national productivity. Pdf alloxaninduced diabetes, a common model for evaluating the. Hypoglycemic effects in alloxaninduced diabetic rats of the phenolic extract from mongolian oak cups enriched in ellagic acid, kaempferol and their.
The rats were divided into following 5 groups of 6 each after the induction of alloxan diabetes. Antidiabetic effect of the egyptian honey bee apis. Rats with blood glucose levels above 250 mgdl were considered diabetic 30 and selected for the study. Effect of aloe vera leaf extract on alloxan induced. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of cs in alloxan. To study the effect of shilajit a herbomineral preparation on blood glucose and lipid profile in euglycemic and alloxaninduced diabetic rats and its effects on the above parameters in. Alloxaninduced diabetes, a common model for evaluating the. Effect of dme on alloxaninduced diabetic rats a total of twenty five 25 diabetic and five 5 normoglycemic rats of both sexes were used. Alloxaninduced insulin release is, however, of short duration and is followed by complete suppression of the islet response to glucose, even when high concentrations 16. Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. Antidiabetic activity of ethanolic extract of tubers of. In alloxan induced diabetic rats, the body weight of the da extract treated animals had shown a significant increase p free radical.
Antioxidant and hypoglycemic activity of strawberry fruit. The rats randomly selected were divided into six 6 groups of five 5 rats per group. Hypoglycemic effects in alloxaninduced diabetic rats of the. The rats were randomly grouped into four as follows. Research article antidiabetic effect of sida cordata in. The oxidative stress induced by alloxan arises due to a compromise in natural antioxidant mechanism and an increase in. Time course effect of alloxan on blood glucose level of rat.
Preventive effects of flavonoids on alloxaninduced. Samson oyebadejo, enoobong bassey, ajayi oyewunmi, victor archibong and ekaete usoro. The mechanism of alloxan and streptozotocin action in b. Five days later, blood samples were drawn and glucose levels were determined to confirm induction of diabetes. Cystoseira myrica aqueous extract on alloxan induced diabetic rats. Antidiabetic effect of hydroalcoholic extract of carthamus tinctorius l. Normal rats given blet 200 mgkg body weight in aqueous solution daily using an intragastric tube for 4 weeks. Antihyperglycemic and antihyperlipidemic effects of. The aim of the present study was the evaluation of possible protective effects of quercetin and chrysin in experimental alloxan induced diabetes in rats. Diabetes mellitus impairs glucose homeostasis causing neurological disorders due to perturbation in utilization of glucose. Effect of luff aegyptica leaf extract on body weigh in alloxan induced diabetic rats. The resulting displaced fracture in diabetic rats requires long periods for remodeling and complete bone consolidation. Allium sativum, alloxan, diabetes mellitus, histopathology, liver and weaning rats. Preventive effects of flavonoids on alloxaninduced diabetes mellitus in rats.
Sulaiman 6 1 department of pharmacology and therapeutics, faculty of medicine. Hypoglycemic and pancreatic protective effects of portulaca oleracea extract in alloxan induced diabetic rats basma k. Forty albino rats 150200 g were randomly selected into 4 groups of 10 rats each, representing normal control, diabetic control, diabetic treated with 14. In alloxaninduced diabetic rats, both the extracts decreased blood sugar. Three groups of 36 rats was induced diabetes with single ip administration of 5% wv of alloxan monohydrate in normal saline. The present study was aimed to evaluate the antidiabetic, antihyperlipidemic and antioxidative activity of. The hypolipidemic effect of leaf essential oil of citrus sinensis in alloxaninduced diabetic rats was evaluated.
In indias indigenous system of medicine, coriandrum sativum cs, commonly used as a food ingredient, is claimed to be useful for various ailments. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and subcutaneous. Cagle university of tennessee knoxville this thesis is brought to you for free and open access by the graduate school at trace. Journal of chemical and pharmaceutical research, 2016, 84. Hypoglycemic and antioxidant effects of leaf essential oil. Histopathological study of the liver of alloxan induced. Effect of shilajit on blood glucose and lipid profile in. Upon alloxan 150mgkg body weight induction, the diabetic animals showed marked increase in the values of plasma glucose, urea, uric acid, creatinine and concomitant decrease in. The effects of alloxan on the histology of the pancreas, thyroid and adrenal glands of the white rat julien l. Research article alloxan induced diabetes mellitus in. Antidiabetic activity of vinca rosea extracts in alloxan. It has been successfully induced in a variety of animal species.
Nigerian honey ameliorates hyperglycemia and dyslipidemia. The rats were divided into four groups as follows after the induction of alloxan. Hypoglycaemic and antidiabetic activity of stem bark extracts. The aim of the present study was the evaluation of possible protective effects of quercetin and chrysin in experimental alloxaninduced diabetes in rats. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal. Diabetic control rats were administered with 150mgkg of alloxan solution, standard pellets and water adlibitum for 21 days. Research article antidiabetic effect of sida cordata in alloxan induced diabetic rats naseeralishahandmuhammadrashidkhan department of biochemistry, faculty of. Diabetes was induced in albino rat models with alloxan monohydrate 40 mgkg. Histopathological changes in diabetic rat organs pancreas, liver and kidney were also.
The effects of alloxan on the histology of the pancreas. Absolute weight of testis, seminal vesicle and prostate gland in control, alloxan. Studies of antidiabetic effect of morinda citrifolia. Antidiabetic, antihypercholestermic and antioxidative. Antidiabetic activity of extract on alloxan induced diabetic rats. This was confirmed through histological examination of the pancreas and liver of alloxan induced diabetic rats. Alloxaninduced diabetes, a common model for evaluating.